“The Greater Good”-
During a cooking class a women passes out and is taken to see House and his team. The team finds out the women gave up her career of doing cancer research in order to do something she liked better. The team ponders over if what they are doing is right for them. Cuddy also gets back at House.
“Big Baby”-
A Special Edu teacher spits up blood and collapses in class is taken to the hospital. As Cuddy is very busy, Cameron ends up doing some of her work. This includes having to deal with house.
“Painless”-
A guy that has constant pain makes a visit to the hospital, Thirteen get treatment by Foreman for the trial on Huntington’s Disease, and Cuddy has to find time to take care of her baby and do her work at the hospital.
“Joy to the World”-
House and his team deal with a bullied girl who collapses during her school’s Christmas program. Meanwhile, Foreman and Thirteen grow closer during the Huntington’s disease drug trials, House gives a patient a gift, the staff wonder who gave House a special gift, and Cuddy gets an unexpected gift.
“Let Them Eat Cake”-
The team take on the case of a fitness guru on an all-natural diet who collapsed while filming a video. Meanwhile, Foreman conducts Huntington’s Disease drug trials and Thirteen signs on as a subject, Cuddy is forced to move into House’s office, and Kutner uses House’s name to run an online medical-advice website.
“Last Resort”-
A man takes over Cuddy’s office and holds House, Thirteen, and several patients hostage. His demand? A diagnosis. The man forces Thirteen to act as a guinea pig for his treatments and House has to end the standoff before a SWAT team opens fire.